Chemical Compounds from Aglaia Plants with Alpha-Glucosidase Inhibitory Activity

Two new rocaglamides and a new nemoralisin-type diterpenoid were isolated from Aglaia odorata and Aglaia lawii plants. The dataset includes spectroscopic characterization data and results from bioactivity assays for alpha-glucosidase inhibition and cytotoxicity. The data was published by Quan H. Pham on figshare under a CC-BY-4.0 license in June 2026.

Use Cases

• Identifying potential lead compounds for diabetes treatment based on alpha-glucosidase inhibitory activity.
• Studying the structure-activity relationships of rocaglamides and nemoralisin-type diterpenoids.
• Comparing the bioactivity of newly isolated compounds against known analogues.
• Validating spectroscopic methods for elucidating the structure of complex natural products.

Strengths

• Includes specific IC50 values for enzyme inhibition, such as 373.81 ± 15.48 µM for nemoralisin P.
• Compares bioactivity results to a positive control (acarbose, IC50 = 416.92 ± 10.93 µM).
• Provides detailed structural elucidation using 1D and 2D NMR spectroscopy.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data files are in PDF and DOCX formats, requiring extraction for computational analysis.

Provenance

Source

figshare

Collection Method

Compounds were isolated from plant material and characterized using spectroscopic methods.

Freshness

Last updated 2026-06-04 09:20:03; freshness should be verified.