RR1 NASA Validation Flight: Mouse Eye Transcriptomic and Epigenomic Data from Spaceflight

NASA's GeneLab project provides transcriptomic and epigenomic data from mouse tissues, including eye, adrenal glands, and muscle, harvested after the first Rodent Research spaceflight experiment. The data results from a multi-omics feasibility study on tissues archived for at least a year at -80°C after return from the International Space Station. This investigation was conducted to assess the viability of RNA, DNA, and protein from these archived samples for high-value spaceflight research.

Use Cases

• Identify spaceflight-induced gene expression changes in mouse eye tissue based on transcriptomic data.
• Analyze epigenetic modifications in space-exposed rodent muscle tissues like the quadriceps and soleus.
• Assess the feasibility of multi-omics analysis on long-term archived biospecimens from space missions.
• Prioritize future rodent research activities on the ISS based on tissue-specific omics data viability.

Strengths

• Data originates from a controlled NASA spaceflight experiment (Rodent Research-1).
• Includes multiple tissue types (e.g., eye, kidney, adrenal glands, several muscles) for cross-tissue analysis.
• Samples were preserved using standardized methods (snap-frozen or RNAlater) and stored at -80°C.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and dataset scale are unknown, which may limit suitability assessment.
• Data is stored in a BIN file format, which may require specialized tools for access and interpretation.

Provenance

Source

National Aeronautics and Space Administration (NASA) GeneLab project.

Collection Method

Tissues were harvested from mice after a spaceflight mission on the International Space Station, preserved, archived, and later processed for RNA, DNA, and protein extraction.

Freshness

Last updated 2026-03-13 19:23:38.204753; freshness should be verified.

Geography

International Space Station (ISS).