RR-1: Mouse Muscle Multi-Omics Data from NASA's First Rodent Research Flight

NASA's GeneLab project provides multi-omics data from the Rodent Research-1 validation flight. The dataset includes transcriptomic, proteomic, and epigenomic data from mouse left gastrocnemius muscle and other tissues, harvested after a year of storage at -80°C. It was published by the National Aeronautics and Space Administration and last updated in March 2026.

Use Cases

• Assess spaceflight effects on muscle transcriptomics based on RNA-seq data from archived tissues.
• Compare proteomic profiles of space-flown versus control mice based on protein extraction results.
• Investigate epigenetic changes in response to microgravity based on DNA methylation or histone modification assays.
• Validate multi-omics analysis protocols for spaceflight biospecimens based on the described extraction and feasibility study.

Strengths

• Data originates from NASA's controlled Rodent Research-1 spaceflight experiment.
• Includes multiple omics layers (transcriptomic, proteomic, epigenomic) for a systems biology approach.
• Tissues were prioritized based on likelihood of significant scientific value for spaceflight research.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and dataset scale are unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

National Aeronautics and Space Administration (NASA) GeneLab project.

Collection Method

Tissues harvested from mouse subjects on the first Rodent Research spaceflight experiment, snap-frozen or RNAlater-preserved, stored at -80°C, and analyzed with multi-omics assays.

Freshness

Last updated 2026-03-13 19:23:16.674770; freshness should be verified.

Geography

International Space Station (ISS).