Rodent Research-1 (RR1): Mouse Liver Multi-Omics Data from NASA Validation Flight

Mouse liver transcriptomic, proteomic, epigenomic and histology data from NASA's Rodent Research-1 (RR1) validation flight. The dataset was produced by the National Aeronautics and Space Administration (NASA) and last updated in March 2026. It is part of the GeneLab data repository and was used to identify systemic biological responses to spaceflight.

Use Cases

• Identify potential 'master regulators' of systemic response to microgravity based on transcriptomic data.
• Validate candidate circulating microRNAs (miRNAs) hypothesized to impact space biology.
• Perform integrative multi-omics analysis linking transcriptomic, proteomic, and epigenomic changes.
• Study the role of TGF-β1 signaling in spaceflight-induced physiological changes.

Strengths

• Data originates from a NASA validation flight, providing a controlled space environment context.
• Includes multiple data modalities: transcriptomic, proteomic, epigenomic, and histology.
• Analysis identified 13 candidate microRNAs common across studies for further investigation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is stored in a BIN format, which may require specialized tools for access and analysis.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Data collected from the Rodent Research-1 (RR1) NASA validation flight and analyzed via systems biology approaches.

Time Range

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Freshness

Last updated 2026-03-13 19:17:12.179501; freshness should be verified.

Geography

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