RR-1 CASIS: Mouse Liver Multi-Omics Data from Microgravity Study

Mouse liver samples from the Rodent Research-1 National Lab experiment were analyzed to study the effect of microgravity on muscle wasting. RNA-Seq, whole genome bisulfite sequencing, and proteomic expression profiling were performed on samples from Flight, Ground Control, and Basal Control groups. The data was generated by the National Aeronautics and Space Administration.

Use Cases

• Identify gene expression changes in liver tissue based on RNA-Seq data mentioned in the description
• Study epigenetic modifications under microgravity based on whole genome bisulfite sequencing data
• Analyze protein expression profiles in response to spaceflight based on proteomic data
• Compare molecular responses across Flight, Ground Control, and Basal Control groups described in the experiment

Strengths

• Data integrates multiple omics layers: transcriptomic, epigenomic, and proteomic
• Includes controlled experimental groups: Flight, Ground Control, and Basal Control
• Samples were collected on-orbit for the Flight group, providing direct spaceflight exposure data

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is stored in BIN format, which may require specialized tools for access and analysis

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experimental data from the Rodent Research-1 (RR-1 CASIS) validation flight, with samples processed on-orbit and on the ground.

Time Range

Samples were dissected 21 or 22 days after launch for the Flight group.

Freshness

Last updated 2026-03-13 19:20:35.331214; freshness should be verified

Geography

Data originates from a spaceflight experiment; specific terrestrial geography is not specified.