Rodent Research-3: Mouse Adrenal Gland Multi-Omic Data from ISS

The Rodent Research-3 mission, sponsored by Eli Lilly and Co. and the Center for the Advancement of Science in Space, studied a potential countermeasure for muscle and bone loss in space. Twenty female BALB/c mice were flown to the International Space Station for 39-42 days, with matched ground and basal control groups. The dataset contains transcriptomic, proteomic, and epigenomic data from the adrenal glands of these mice, all of which received only a control/sham injection.

Use Cases

• Identify gene expression changes in adrenal glands based on transcriptomic data from spaceflight.
• Analyze protein abundance shifts based on proteomic data from mice exposed to microgravity.
• Study epigenetic modifications based on epigenomic data from spaceflight and control groups.
• Compare multi-omic profiles between spaceflight, ground control, and basal control cohorts.

Strengths

• Data is derived from a controlled experiment with 20 mice on the ISS and 40 matched ground/basal controls.
• Includes multi-omic data types (transcriptomic, proteomic, epigenomic) from the same biological samples.
• Experimental conditions were standardized with mice housed in identical hardware for flight and ground controls.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is stored in a BIN format, which may require specialized tools for access and analysis.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Data collected from a controlled rodent research mission on the International Space Station.

Freshness

Last updated 2026-03-13 19:28:51.972467; freshness should be verified.

Geography

International Space Station and associated ground control facilities.