Rodent Research-3: Mouse Multi-Omic Data from ISS and Ground Controls

The Rodent Research-3 mission, sponsored by Eli Lilly and Co. and the Center for the Advancement of Science in Space, generated transcriptomic, proteomic, and epigenomic data from mouse kidneys. Data comes from 40 female BALB/c mice, with 20 flown to the International Space Station for 39-42 days and 20 used as ground controls. All mice in this specific dataset received only a control/sham injection.

Use Cases

• Identify gene expression changes in kidney tissue based on transcriptomic data from spaceflight.
• Compare protein abundance profiles based on proteomic data between spaceflight and ground control groups.
• Analyze epigenetic modifications based on epigenomic data from mice exposed to microgravity.
• Study the integrated molecular response to spaceflight based on multi-omic data from a controlled rodent model.

Strengths

• Data originates from a controlled experiment with 40 mice across spaceflight, ground control, and basal groups.
• Includes matched transcriptomic, proteomic, and epigenomic data from the same biological samples.
• Experimental conditions for ground controls matched ISS environmental conditions in identical hardware.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and dataset scale are unknown, which may limit suitability assessment.
• Data is stored in a BIN file format, which may require specialized tools for access and analysis.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Data collected from a controlled rodent experiment on the International Space Station and matching ground controls.

Freshness

Last updated 2026-03-13 19:28:37.762266; freshness should be verified.

Geography

International Space Station and ground-based laboratories.