Rodent Research-3: Mouse Liver Multi-Omics and Histology from ISS Mission

Twenty BALB/c female mice were flown to the International Space Station for 39-42 days as part of the Rodent Research-3 mission sponsored by Eli Lilly and Co. and the Center for the Advancement of Science in Space. The dataset includes liver transcriptomic, proteomic, epigenomic, and histology data from these spaceflight mice, along with ground and basal control groups. Data was collected by the National Aeronautics and Space Administration and last updated in March 2026.

Use Cases

• Identify transcriptomic signatures of spaceflight in mouse liver tissue.
• Compare proteomic profiles between spaceflight, ground control, and basal control groups.
• Analyze epigenetic changes associated with prolonged microgravity exposure.
• Correlate histological observations with molecular omics data from the same subjects.

Strengths

• Includes data from a controlled experiment with 20 mice flown to the ISS and 40 total mice across all groups.
• Provides multimodal data (transcriptomic, proteomic, epigenomic, histology) from the same biological samples.
• Experimental design includes spaceflight, ground control, and basal control groups for robust comparison.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• All mice received only a control/sham injection, limiting analysis to the effects of spaceflight without a therapeutic countermeasure.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Data collected from the Rodent Research-3 mission on the International Space Station, with matching ground control experiments.

Time Range

The mission duration was 39-42 days.

Freshness

Last updated 2026-03-13 19:27:35.334108; freshness should be verified.

Geography

Data collection involved the International Space Station and ground-based facilities.