Rat Study Data on DEHP Nephrotoxicity and 4-PBA Intervention

24 Wistar albino rats were divided into four groups to investigate the role of endoplasmic reticulum stress in DEHP-induced kidney damage and the therapeutic effect of 4-PBA. The dataset comprises biochemical measurements (creatinine, urea, BUN), protein expression levels of ER stress markers (GRP78, CHOP, Caspase 12), and histological assessments from a 28-day controlled animal study. Authored by Mohammed Nazish Quasmi and published on figshare in 2026.

Use Cases

• Predict renal dysfunction severity from creatinine, urea, and BUN levels using regression models.
• Classify treatment efficacy (control, DEHP, 4-PBA co-treatment) based on protein expression data for GRP78, CHOP, and Caspase 12.
• Analyze correlations between oxido-nitrosative stress markers and histological damage scores.
• Model the dose-response relationship of 4-PBA (500 mg/kg vs. 1000 mg/kg) on attenuating biochemical aberrations.

Strengths

• Controlled experimental design with 24 subjects across 4 distinct treatment groups.
• Multimodal data includes biochemical assays, protein expression quantification, and histological analysis.

Limitations

• Small sample size of 6 rats per group limits statistical power for generalizable conclusions.
• Data is confined to a single animal model (Wistar albino rats) and may not translate directly to other species.
• Temporal coverage is limited to a single 28-day experiment.

Provenance

Source

figshare, authored by Mohammed Nazish Quasmi.

Collection Method

Laboratory experiment on Wistar albino rats with controlled oral administrations of DEHP and 4-PBA.

Time Range

Experimental period of 28 days.

Freshness

Last updated in 2026, indicating recent research.

Geography

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