Xylopic Acid: Gut Microbiota and Anti-Arthritis Activity in Mice

Purevdulam Khongorzul's dataset investigates the anti-rheumatoid arthritis activity of Xylopic acid (XA) in collagen-induced arthritic mice, with a focus on the role of the gut microbiota. It includes 16S rRNA gene sequencing data from mouse fecal samples, revealing altered microbial abundance and diversity from phylum to genus level. The data also covers in vitro anaerobic metabolism of XA by human volunteer microbiota, identifying six metabolites.

Use Cases

• Analyzing gut microbiota taxonomic shifts from phylum to genus in arthritic mice treated with Xylopic acid.
• Correlating microbial genera like Faecalibacterium and Bacteroides with changes in pro-inflammatory cytokines.
• Comparing in vivo mouse and in vitro human metabolite profiles of Xylopic acid breakdown.
• Studying the resolution of microbial dysbiosis in a collagen-induced arthritis model.

Strengths

• Includes 16S rRNA sequencing data with taxonomic resolution from phylum to genus level.
• Links compound metabolism to specific microbial genera (e.g., Faecalibacterium, Bacteroides).
• Combines in vivo mouse model data with in vitro human volunteer metabolite confirmation.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column names and exact row counts are not provided, limiting understanding of data structure.
• The dataset size (7,621,069 bytes) is given, but its composition (e.g., sequence files, spreadsheets) is unclear.
• Human in vitro data is from only two volunteers, limiting generalizability.

Provenance

Source

Purevdulam Khongorzul

Collection Method

16S rRNA gene sequencing of mouse fecal samples and in vitro anaerobic metabolism assays with human microbiota.

Freshness

Last updated March 20, 2026.