Roles of FXR in Lipid Biochemistry within Hepatocellular Carcinoma Using MALDI MSI

Kayle J. Bender uploaded a dataset on figshare in April 2026 investigating lipid composition in hepatocellular carcinoma (HCC). The dataset likely contains mass spectrometry imaging (MALDI MSI) data focused on phosphatidylcholine (PC) species, comparing HCC and nontumorous liver regions. The study hypothesizes a role for PC(38:4) based on cell culture experiments with Hep3B cells.

Use Cases

• Analyze spatial distribution of phosphatidylcholine lipids based on MALDI MSI data.
• Compare lipid profiles between hepatocellular carcinoma and nontumorous tissue regions.
• Investigate the hypothesized role of PC(38:4) in HCC progression.
• Study the influence of the farnesoid X receptor (FXR) on liver lipid metabolism in cancer.

Strengths

• Dataset employs MALDI MSI, a technique suited for spatially resolved molecular analysis of lipids.
• Focus on phosphatidylcholine species provides a specific molecular target for investigation.
• Includes data from cell culture experiments with Hep3B cells incubated with PC(38:4).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Dataset size is 90.6 KB, indicating a very limited scope.

Provenance

Source

figshare

Collection Method

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI).

Freshness

Last updated 2026-04-25 13:31:40; freshness should be verified.