Mouse Hepatic Fibrosis Proteomics by CCl4 Administration Route

Proteomic data compares liver fibrosis severity in mice induced by three carbon tetrachloride (CCl4) administration routes: intraperitoneal (IP), subcutaneous (SC), and intragastric (IG). The study, by Ping Tao, identifies distinct molecular pathways associated with each route, with IG causing the most severe fibro-inflammatory injury. The dataset is provided in an XLSX file.

Use Cases

• Compare proteomic profiles from intraperitoneal, subcutaneous, and intragastric administration routes to identify route-specific molecular signatures.
• Analyze conserved profibrotic mechanisms and hub gene patterns in hepatic ECM remodeling and metabolism across species.
• Evaluate the correlation between administration route and fibrotic severity to refine experimental models for human hepatic fibrosis.

Strengths

• Directly compares three distinct CCl4 delivery methods (IP, SC, IG) for modeling hepatic fibrosis.
• Proteomic profiling identifies specific molecular pathways like tissue remodeling and immune activation linked to each route.
• Includes cross-species analysis highlighting conserved profibrotic mechanisms between mice and humans.

Limitations

• The dataset is small at 1.1 MB, suggesting limited scope or sample size for proteomic analysis.
• Data is derived solely from a controlled mouse model, limiting direct applicability to human clinical contexts.
• Unknown row and column counts prevent assessment of the dataset's statistical power and feature dimensionality.

Provenance

Source

figshare, authored by Ping Tao.

Collection Method

Comparative proteomics analysis of liver tissue from CCl4-induced mouse models.

Freshness

Last updated March 24, 2026.