RPS6KA3/RSK2-DRAM2 Phosphorylation Study in Melanoma

A research article identifies RPS6KA3/RSK2 phosphorylation of DRAM2 at Ser263 as a key regulator of lysosomal trafficking and autophagic flux. The study, authored by Ga-Eun Lee and published on figshare, includes bioinformatic analyses correlating kinase and DRAM2 expression with melanoma patient prognosis. Findings suggest this signaling axis may be a therapeutic target for autophagy-associated cancers.

Use Cases

• Investigate kinase-substrate interactions based on the described RPS6KA3/RSK2-DRAM2 phosphorylation event.
• Study protein trafficking pathways based on the AP3D1/AP-3-dependent lysosomal targeting mechanism.
• Analyze correlations between gene expression and cancer prognosis based on the bioinformatic findings in melanoma tissues.
• Model the functional bifurcation between autophagy and exosome secretion based on the DRAM2 phosphorylation switch.

Strengths

• Includes experimental findings on a specific phosphorylation site (Ser263) and its functional consequences.
• Links molecular mechanism to clinical relevance via bioinformatic correlation with patient prognosis.
• Provides in vitro and in vivo validation of the DRAM2 S263A mutant's effect on melanoma progression.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset consists of PDF and DOCX files (4.4 MB), suggesting it is a research article rather than structured data tables.

Provenance

Source

figshare

Collection Method

Experimental cell biology and bioinformatic analysis, as described in the article.

Freshness

Last updated 2026-04-30 11:40:03; freshness should be verified.