S1 Table: Drosophila Trio Protein Epistatic Mutations and Fitness Effects

Flora Borne's dataset provides evidence for intramolecular epistasis constraining protein evolution. It contains data from a population genetic screen for clustered adaptive amino acid substitutions in Drosophila proteins. The dataset likely includes experimental results from reconstructing evolutionary intermediates of the Trio protein via genome editing.

Use Cases

• Modeling fitness landscapes based on viability and locomotor defect measurements.
• Analyzing epistatic constraints on evolutionary trajectories from reconstructed intermediate states.
• Studying the role of heterozygosity in circumventing maladaptive intermediate states during adaptation.

Strengths

• Data is associated with a published experimental proof-of-concept on the Trio protein.
• Dataset is openly licensed under CC-BY-4.0 for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 5.6 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Data likely originates from a population genetic screen and subsequent genome editing experiments in Drosophila.

Freshness

Last updated 2026-06-03 17:45:50; freshness should be verified.