S100P Proteomics Data for Distal Cholangiocarcinoma Prognosis

Proteomic profiling of 18 surgical samples from patients with distal cholangiocarcinoma identified 6804 proteins. The dataset includes differential expression analysis revealing 219 proteins upregulated in patients with early recurrence. Author Hyemin Kim published this data on figshare in May 2026.

Use Cases

• Validate S100P as a prognostic biomarker based on its association with recurrence and mortality hazard ratios.
• Investigate extracellular matrix and cellular interaction pathways from the 219 upregulated proteins linked to early recurrence.
• Perform independent immunohistochemical validation using the described cohort of 26 tissue microarray samples.

Strengths

• Includes validation on an independent cohort of 26 tissue microarray samples.
• Identified 6804 proteins from 18 patient samples, providing a broad proteomic profile.
• Reports specific hazard ratios (HR 4.55 for recurrence, HR 4.99 for mortality) for the biomarker S100P.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Sample size is limited to 18 surgical samples for the primary proteomic analysis.

Provenance

Source

figshare

Collection Method

Shotgun liquid chromatography with tandem mass spectrometry on surgical samples.

Freshness

Last updated 2026-05-15 07:53:56; freshness should be verified.