Flora Borne's dataset provides evidence for intramolecular epistasis in protein evolution. It likely contains data from a population genetic screen identifying spatially-clustered adaptive amino acid substitutions in Drosophila proteins, with a case study on the Trio protein. The dataset was last updated on June 3, 2026.
Use Cases
- Identify candidate proteins for functional analysis based on spatially-clustered substitutions mentioned in the description.
- Analyze constraints on evolutionary trajectories using reconstructed intermediate states described in the study.
- Investigate the role of recessive deleterious effects in circumventing evolutionary constraints as discussed in the description.
Strengths
- Provides direct empirical evidence for intramolecular epistatic interactions, a topic described as having limited evidence.
- Includes a proof-of-concept functional analysis of the Trio protein with three spatially-clustered substitutions.
- Data is openly available under a CC-BY-4.0 license.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- The dataset is very small (6.3 KB), indicating a limited scope.
Provenance
- Source
- figshare
- Collection Method
- Likely derived from a population genetic screen and systematic reconstruction of evolutionary intermediates using genome editing.
- Freshness
- Last updated 2026-06-03 17:45:52; freshness should be verified.