Salarin C Activity on Chronic Myeloid Leukemia Cells Under Hypoxia

A research dataset from paperswithcode by Edoardo Del Poggetto investigates the anticancer macrolide salarin C. The study examines its effects on chronic myeloid leukemia cells, particularly after incubation in 0.1% oxygen, measuring outcomes like apoptosis and stem cell potential inhibition. The work suggests a potential use for suppressing cells refractory to standard tyrosine kinase inhibitors.

Use Cases

• Modeling drug response based on concentration-dependent inhibition of stem cell potential mentioned in the description
• Analyzing cell survival and apoptosis patterns under hypoxic conditions described in the study
• Investigating the relationship between BCR/Abl signaling maintenance and drug sensitivity as discussed in the results

Strengths

• Dataset is derived from a described experimental study on primary cells and cell lines
• Research context is clearly defined, focusing on a specific drug (salarin C) and condition (0.1% oxygen)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Last update date is unknown; freshness unverified

Provenance

Source

paperswithcode

Collection Method

Likely contains experimental results from laboratory cell culture studies described in the associated research.