Synthetic Route Data for Seven-Membered Tricyclic Indole Scaffolds

A synthetic chemistry dataset from figshare, authored by Olga I. Adaeva and last updated on 2026-05-19. It describes an improved and scalable route to seven-membered 3,4-fused tricyclic indole scaffolds, including preliminary biological evaluation results.

Use Cases

• Modeling synthetic pathways for conformationally fixed aminobenzosuberene analogues based on the described route.
• Training predictive models for regioselective Fischer indolization outcomes based on the Sc(OTf)3-promoted reaction.
• Virtual screening for antimitotic compounds based on the scaffold framework and preliminary activity data.

Strengths

• Dataset size is 6.3 MB, indicating a focused and manageable download.
• The description provides specific chemical identifiers (e.g., compound 1b, 5b) and a biological activity threshold (0.2 μM).
• The synthetic route is described as having good overall efficiency and reproducibility.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The description is focused on methodology; the specific data file contents and structure are not detailed.

Provenance

Source

figshare, author Olga I. Adaeva.

Collection Method

Likely contains experimental data from the reported chemical synthesis and biological evaluation.

Freshness

Last updated 2026-05-19 19:35:52.