ToxCast Chemical Library Binding Assays for Transthyretin

Supporting data for a 2024 study screening chemical libraries for binding to the protein transthyretin. The U.S. Environmental Protection Agency produced this dataset, which includes experimental results published in Chemical Research in Toxicology. Files are available in PDF and XLS formats.

Use Cases

• Identify chemicals with high binding affinity to transthyretin using assay result columns for prioritization.
• Analyze dose-response relationships from concentration and binding activity data fields.
• Correlate chemical structural features from the ToxCast library with protein binding outcomes.
• Validate computational binding prediction models against experimental screening data.

Strengths

• Data is peer-reviewed and published in a 2024 American Chemical Society journal.
• Originates from the authoritative U.S. Environmental Protection Agency ToxCast program.

Limitations

• Sample size and specific row/column counts are unknown from the description.
• Data is static and associated with a single 2024 publication, with no stated update plan.

Provenance

Source

U.S. Environmental Protection Agency.

Collection Method

Experimental screening of the ToxCast chemical libraries for protein binding.

Time Range

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Freshness

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Geography

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