ToxCast Chemical Library Screening for Transthyretin Binding

Supporting data from a 2024 study screening chemical libraries for binding to the protein transthyretin. The dataset is associated with a peer-reviewed publication in Chemical Research in Toxicology by researchers from the U.S. Environmental Protection Agency. It includes experimental results and supporting information provided in PDF and XLS file formats.

Use Cases

• Analyze binding affinity scores for ToxCast chemicals against transthyretin to identify potential endocrine disruptors.
• Correlate chemical structures or properties from the library with experimental binding results for predictive modeling.
• Validate computational docking or QSAR models using the published experimental screening data.

Strengths

• Data is peer-reviewed and published in a 2024 American Chemical Society journal.
• Associated with the extensive, well-characterized U.S. EPA ToxCast chemical library.

Limitations

• Specific row count, column names, and sample size of the screening data are unknown.
• Data format includes PDFs which require extraction for computational analysis.

Provenance

Source

U.S. Environmental Protection Agency (EPA).

Collection Method

Experimental screening of the ToxCast chemical libraries for protein binding.

Time Range

Study published in 2024.

Freshness

Dataset was last updated on the platform in April 2026, with underlying research published in 2024.

Geography

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