Second-Generation Anti-Tubercular Squaramides: Potency and Metabolic Stability Data

A dataset from figshare, authored by Nada Mosallam and last updated on April 23, 2026, describing lead optimization efforts for anti-tuberculosis squaramide compounds. It likely contains data on compound analogues, their potency measured in nanomolar (nM) concentrations, and metabolic stability metrics. The dataset is small, at 4.5 KB, and is available in CSV format.

Use Cases

• Modeling structure-activity relationships based on squaramide analogue potency data.
• Analyzing metabolic stability trends across compound series mentioned in the description.
• Comparing drug resistance profiles based on minimum inhibitory concentration (MIC) shifts for bedaquiline-resistant mutants.
• Identifying lead compounds with balanced potency and stability for preclinical candidate selection.

Strengths

• Specific potency values are provided, such as 51 nM for analogue 20j.
• Includes comparative data on resistance, noting a 2-fold vs. 16-fold MIC shift for a key compound.
• Data is associated with published research on lead optimization and in vivo mouse model results.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (4.5 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from medicinal chemistry research.

Time Range

Publication date suggests research circa 2026.

Freshness

Last updated 2026-04 23 12:05:22; freshness should be verified.

Geography

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