SDIPTACs: Self-Dimerization Induced Proximity Targeting Chimeras for HIV Inhibition

Seven novel compounds called SDIPTACs were designed to inhibit HIV-1 replication by inducing artificial dimerization of the DCAF1 protein. Biophysical data and crystal structures for four DCAF1-SDIPTAC-DCAF1 ternary complexes are included, revealing details on complex stability and conformation. The dataset, authored by Mark F. Mabanglo and shared on figshare in May 2026, supports the development of therapeutics for HIV and other diseases.

Use Cases

• Analyzing compound efficacy based on biophysical data and crystal structures mentioned in the description
• Modeling protein-protein interactions based on the described DCAF1-DCAF1 complex conformations
• Screening for novel HIV therapeutics based on the unique mechanism of Vpr-DCAF1 interaction blockade
• Studying structure-activity relationships for self-dimerization inducing compounds

Strengths

• Includes biophysical data and crystal structures for four distinct ternary complexes
• Contains data on seven specifically synthesized compounds (SDIPTACs)
• Demonstrates functional inhibition of Vpr-dependent HIV replication in CD4+ T cells for two compounds

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 2.3 KB file size suggests a very limited scope, likely containing summary or key results rather than raw experimental data

Provenance

Source

Mark F. Mabanglo

Collection Method

Experimental design, synthesis, and biophysical/crystallographic analysis as described.

Freshness

Last updated 2026-05-18 18:34:01; freshness should be verified