Serum FGL2 Levels and HK-2 Cell Data for Diabetic Nephropathy Study

A clinical and in vitro study investigating fibrinogen-like protein 2 (FGL2) in diabetic nephropathy. Serum FGL2 levels were measured in 105 patients with type 2 diabetes and 110 healthy controls, and HK-2 cells were used for mechanistic experiments. The dataset was authored by Xiao Gang Lu and shared under a CC-BY-4.0 license on figshare.

Use Cases

• Correlating serum biomarker levels with disease severity based on albuminuria stratification
• Investigating associations between FGL2 and metabolic parameters like glycemic indices and insulin resistance
• Analyzing links between FGL2 and renal injury markers such as NGAL and KIM-1
• Studying the role of the PI3K/Akt-FoxO1 signaling pathway in high glucose-induced tubular dysfunction

Strengths

• Includes data from a defined clinical cohort of 105 patients and 110 controls
• Mechanistic in vitro experiments using HK-2 cells with pathway-specific inhibition
• Correlations analyzed with multiple clinical parameters including injury, inflammation, and fibrosis markers

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is small, totaling 503.5 KB, indicating limited scope

Provenance

Source

figshare

Collection Method

Clinical serum measurements and controlled laboratory cell experiments.

Freshness

Last updated 2026-05-21 02:28:49; freshness should be verified