KDM6A Study: Sex-Specific Epigenetic Regulation of Liver Cholesterol and Atherosclerosis

A 3.0 MB dataset from figshare, last updated May 1, 2026, containing raw experimental data for a study on epigenetic regulation in liver cholesterol metabolism. The data, authored by Lin Chen under a CC-BY-4.0 license, includes qPCR results, mouse phenotype analysis, and original western blot files. The study investigates the role of the KDM6A gene in sex-specific epigenetic reprogramming of hepatocytes linked to atherosclerosis.

Use Cases

• Validate gene expression changes based on qPCR data mentioned in the description
• Analyze correlations between epigenetic modifications and phenotypic outcomes based on integrated transcriptome, cistrome, epigenome, and proteome data
• Investigate sex-specific differences in cholesterol and lipoprotein metabolism pathways described in the study
• Reproduce or extend western blot analyses using the provided original files

Strengths

• Data is openly licensed under CC-BY-4.0, facilitating reuse and redistribution.
• Integrates multiple 'omics' data types (transcriptome, cistrome, epigenome, proteome) as described, providing a multi-faceted view.
• Includes raw experimental files (western blot originals), which supports reproducibility.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain statistical analyses.
• The dataset's 3.0 MB size suggests a relatively small experimental scale.

Provenance

Source

figshare

Collection Method

Generated from laboratory experiments on human liver cell lines and mouse models, integrating systemic analyses.

Time Range

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Freshness

Last updated 2026-05-01 07:01:03; freshness should be verified.

Geography

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