Shared Genetics of Anterior Uveitis and IBD, GWAS Analysis

Shared Genetics Implicate Gut Microbiota and Immunity in Anterior Uveitis and Inflammatory Bowel Disease is a dataset from figshare by Gangyi Li, last updated April 2026. It contains results from genetic analyses, including GWAS data, Mendelian randomization, and multi-trait colocalization with 412 gut microbiome features. The dataset identifies 62 pleiotropic risk loci and explores causal links between IBD subtypes and anterior uveitis.

Use Cases

• Identify shared genetic loci between autoimmune diseases based on GWAS data.
• Investigate causal relationships between IBD subtypes and anterior uveitis using Mendelian randomization results.
• Explore links between disease risk loci and gut microbiome features via multi-trait colocalization analysis.
• Analyze enrichment of pleiotropic loci in immune pathways like the IL-17/IL-23 axis and NOD2 signaling.
• Screen for potential drug targets among pleiotropic genes such as JAK2 and STAT3.

Strengths

• Includes results from large-scale GWAS data from European-ancestry cohorts.
• Integrates 412 gut microbiome features for multi-trait colocalization analysis.
• Identifies 62 pleiotropic risk loci with functional annotation.
• Reports significant genetic correlations (rg=0.44 for IBD) and causal inference results.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the European-ancestry cohorts used.

Provenance

Source

figshare, author Gangyi Li.

Collection Method

Analysis performed using LD score regression, two-sample Mendelian randomization, PLACO, HyPrColoc, FUMA, ANNOVAR, MAGMA, and DrugBank.

Freshness

Last updated 2026-04-17 17:39:59; freshness should be verified.

Geography

European-ancestry cohorts.