PM2.5 Exposure, Cognitive Scores, and DNA Methylation Data from 1777 Adults

A dataset from the Guangxi Eco-Environmental Health and Aging Study (GEHAS) includes 3554 observations from 1777 middle-aged and older adults. It examines associations between short-term PM2.5 exposure, cognitive function measured by Mini-Mental State Examination (MMSE) scores, and DNA methylation at circadian rhythm gene CpG sites. The dataset was authored by Jiahui Rong and last updated on 2026-04 14.

Use Cases

• Modeling the association between short-term PM2.5 exposure and cognitive decline based on MMSE scores.
• Analyzing DNA methylation signatures at CpG sites linked to circadian rhythm genes.
• Conducting subgroup analyses (e.g., by sex or age) on PM2.5 exposure effects.
• Investigating epigenetic mediation pathways, such as the role of specific CpG sites like cg25579477 in PRKAG2.

Strengths

• Includes 3554 observations from a cohort of 1777 individuals.
• Provides specific effect sizes (e.g., a 0.474-point reduction in MMSE per 5 μg/m³ PM2.5 increase).
• Contains DNA methylation data for 552 participants, identifying 44 CpG sites associated with exposure.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary data tables is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the Guangxi-based GEHAS study.

Provenance

Source

Guangxi Eco-Environmental Health and Aging Study (GEHAS).

Collection Method

Observational study data collection.

Time Range

Time range of the underlying study is not specified.

Freshness

Last updated 2026-04-14 11:04:10; freshness should be verified.

Geography

Likely Guangxi, China, based on the study name.