Simulated Placental Malaria Vaccine Trial Data for Endpoint Selection

Simulated data supporting a 2026 manuscript on endpoint selection for placental malaria vaccine efficacy trials. The data were generated using a simulation framework to evaluate candidate endpoints including time to detected pregnancy and healthy live birth. The dataset, created by Jeroen Bok, is 27.0 MB in size and available under a CC-BY-4.0 license.

Use Cases

• Power analysis for vaccine trials based on simulated sample sizes and effect sizes
• Comparing statistical endpoints like pregnancy loss rates based on simulated pregnancy outcomes
• Evaluating trial design scenarios based on varied assumptions about pregnancy rates and neonatal mortality

Strengths

• Data is explicitly simulated for a specific research purpose, supporting the manuscript "Endpoint selection for placental malaria vaccine efficacy trials"
• Companion R code and an interactive Shiny application are provided for reproducibility and scenario exploration
• Dataset size is 27.0 MB, indicating a contained and likely manageable volume for analysis

Limitations

• Data is entirely simulated, not observational or clinical, limiting real-world generalizability
• Row count and column-level documentation are unknown, which may limit suitability assessment
• Description metadata is limited; actual data structure and field semantics must be inferred after download

Provenance

Source

Jeroen Bok via figshare

Collection Method

Generated via a simulation framework as described in the supporting manuscript.

Freshness

Last updated 2026-05-08 15:06:50