Oxidized Macrolide Antibiotic Compounds with Anti-MRSA Activity

A suite of oxidized macrolide antibiotic derivatives synthesized from erythromycin A, clarithromycin, and azithromycin. The dataset includes results from antimicrobial activity testing against a broad range of pathogens, including CA-MRSA and MRSA(mph(C)). The data was authored by Olivia C. Langner and last updated on March 17, 2026.

Use Cases

• Training predictive models for antibiotic activity based on chemical modification data.
• Identifying structure-activity relationships for macrolide derivatives against resistant pathogens.
• Screening for novel anti-MRSA compounds based on the newly installed carbonyl groups.
• Comparing the efficacy of synthesized analogs against the clinical parent compounds.

Strengths

• Includes compounds with demonstrated activity against CA-MRSA and MRSA(mph(C)), where clinical analogs showed none.
• Data is derived from a systematic methodology using a newly designed azaadamantyl oxoammonium catalyst.
• File size is 272.3 MB, indicating a medium-scale dataset.

Limitations

• Row count and column definitions are unknown, limiting suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect experimental bias inherent to the specific synthesis methodology.

Provenance

Source

figshare

Collection Method

Synthetic chemistry and subsequent antimicrobial activity testing.

Time Range

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Freshness

Last updated 2026-03 17 15:06:16.

Geography

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