Oxidized Macrolide Antibiotic Compounds with Broad Spectrum and Anti-MRSA Activities

A suite of oxidized macrolide antibiotic derivatives was synthesized using a new azaadamantyl oxoammonium catalyst. Olivia C. Langner published this dataset on figshare in March 2026, detailing compounds derived from erythromycin A, clarithromycin, and azithromycin. Three of the compounds reported show antibiotic activity against CA-MRSA and MRSA strains where the clinical parent compounds are ineffective.

Use Cases

• Training predictive models for antibiotic activity based on chemical modifications of macrolide scaffolds.
• Analyzing structure-activity relationships for compounds with activity against MRSA strains.
• Benchmarking synthetic methodologies for site-selective oxidation of complex natural products.

Strengths

• Compounds were tested for antimicrobial activity against a broad range of pathogens.
• Three compounds show activity against MRSA strains where parent clinical analogs have none.
• Dataset size is 221.0 MB, suggesting substantial chemical data.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Olivia C. Langner via figshare.

Collection Method

Synthesized via site-divergent oxidation of erythromycin A, clarithromycin, and azithromycin using a designed catalyst.

Time Range

Publication date is 2026-03-17.

Freshness

Last updated 2026-03-17 15:05:50; freshness should be verified.

Geography

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