Oxidized Macrolide Antibiotic Derivatives with Anti-MRSA Activity

Olivia C. Langner published a dataset on figshare in March 2026 detailing the synthesis and testing of novel macrolide antibiotic derivatives. The data likely contains results from site-selective oxidation experiments on erythromycin A, clarithromycin, and azithromycin, generating a suite of compounds. Antimicrobial activity testing against a broad range of pathogens, including CA-MRSA and MRSA(mph(C)), is described.

Use Cases

• Training predictive models for antibiotic activity based on chemical modification data mentioned in the description.
• Analyzing structure-activity relationships for macrolide derivatives based on the newly installed carbonyl groups.
• Benchmarking synthetic methodologies for site-selective oxidation of complex natural products.
• Identifying candidate compounds with activity against resistant pathogens like MRSA based on the reported testing.

Strengths

• Data is associated with a specific, peer-reviewed-sounding methodology for site-selective oxidation.
• Includes activity testing results against a broad range of pathogens and specific MRSA strains.
• Compounds are derived from three clinically relevant macrolide scaffolds (erythromycin A, clarithromycin, azithromycin).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.
• The 6.1 MB file size suggests a relatively small dataset.

Provenance

Source

figshare, author Olivia C. Langner.

Collection Method

Likely contains experimental data from chemical synthesis and antimicrobial activity testing.

Time Range

null

Freshness

Last updated 2026-03-17 15:06:03; freshness should be verified.

Geography

null