Oxidized Macrolide Antibiotic Derivatives with Anti-MRSA Activity

A dataset from figshare describes the synthesis and antimicrobial testing of oxidized derivatives of erythromycin A, clarithromycin, and azithromycin. The data, authored by Olivia C. Langner and last updated in March 2026, includes results from applying a new azaadamantyl oxoammonium catalyst to achieve site-divergent oxidations. Multiple compounds were reported to retain broad-spectrum activity and some show activity against CA-MRSA and MRSA strains where clinical analogs were ineffective.

Use Cases

• Training predictive models for antibiotic activity based on chemical modification data.
• Analyzing structure-activity relationships for macrolide antibiotic derivatives.
• Screening for potential lead compounds with activity against methicillin-resistant Staphylococcus aureus (MRSA).

Strengths

• Dataset size is 127.6 MB, indicating a medium-scale data volume.
• Includes results for compounds tested against CA-MRSA and MRSA(mph(C)), where clinical analogs showed no activity.
• Data is associated with a described methodology for site-divergent oxidation using a newly designed catalyst.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The description does not specify the exact number of compounds or the full data structure.
• Data may reflect the specific experimental bias of the described synthetic methodology.

Provenance

Source

figshare

Collection Method

Experimental synthesis and antimicrobial activity testing described in the associated research.

Time Range

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Freshness

Last updated 2026-03-17 15:05:55

Geography

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