Oxidized Macrolide Antibiotic Derivatives with Anti-MRSA Activity

A dataset from 2026 describes the synthesis and antimicrobial testing of a suite of oxidized macrolide antibiotic derivatives. The compounds were generated via site-selective oxidation of erythromycin A, clarithromycin, and azithromycin using a newly designed catalyst. The work by Olivia C. Langner includes activity data against a broad range of pathogens and specific activity against CA-MRSA and MRSA strains.

Use Cases

• Training predictive models for antibiotic activity based on chemical modification data mentioned in the description
• Analyzing structure-activity relationships for macrolide derivatives against MRSA strains
• Benchmarking synthetic methodologies for site-selective oxidation of complex natural products

Strengths

• Dataset size is 132.4 MB, indicating a medium-scale data collection
• Includes activity data against CA-MRSA and MRSA strains where clinical analogs showed no activity
• Compounds are derived from three established macrolide scaffolds: erythromycin A, clarithromycin, and azithromycin

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Synthetic chemistry and antimicrobial activity testing as described in the associated research.

Time Range

2026

Freshness

Last updated 2026-03-17 15:06:01; freshness should be verified

Geography

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