Site-Specific IgG N-Glycosylation Profiles for Multiple Myeloma Diagnosis and Monitoring

Quantitative glycoproteomic profiles of monoclonal immunoglobulins from a clinical cohort of 81 patients and 26 healthy controls. The dataset includes longitudinal samples from 14 newly diagnosed, 7 partial response, and 5 complete response patients. It was created by Rui Zhao and published on figshare in June 2026.

Use Cases

• Diagnostic model development based on the site-specific glycoform IgG1H4N4F1S1.
• Analysis of sialylation dynamics based on longitudinal tracking of glycopeptide abundance.
• Correlation studies between glycosylation signatures and clinical parameters mentioned in the description.

Strengths

• Includes longitudinal data from 26 patients across three clinical response stages.
• Contains data from a cohort of 81 patients (MGUS and MM) and 26 healthy controls.
• Validation set of 28 samples is mentioned.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Integrated workflow coupling serum protein electrophoresis with ZenoTOF mass spectrometry.

Freshness

Last updated 2026-06-01 18:08:44; freshness should be verified.