SLC25A51: Metabolic Data on AML Cell Proliferation Control

Lu et al. investigated the role of mitochondrial transporter SLC25A51 in Acute Myeloid Leukemia. The dataset, harvested by the Texas Data Repository and last updated on March 18, 2024, likely contains results from orthotopic xenograft models and metabolic flux analyses showing how SLC25A51 decouples the NAD+/NADH ratio to support cancer cell proliferation.

Use Cases

• Modeling the link between SLC25A51 expression and patient outcomes based on correlation analysis mentioned in the description.
• Investigating metabolic pathway shifts, such as glutamine utilization for reductive carboxylation, following SLC25A51 depletion.
• Identifying potential drug sensitivities, like to glutaminase inhibitor CB-839, based on experimental results described.
• Analyzing the relationship between mitochondrial NAD+ import and apoptosis in cancer cells from the xenograft model data.

Strengths

• Data is linked to specific experimental models, including orthotopic xenografts and metabolic flux analyses.
• Findings are connected to patient outcome data, suggesting clinical relevance.
• Last updated on 2024-03-18, indicating recent availability.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Texas Data Repository Harvested Dataverse

Collection Method

Likely experimental data from laboratory studies.

Time Range

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Freshness

Last updated 2024-03-18 06:29:56; freshness should be verified.

Geography

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