Astronaut Plasma sEV Small-RNA Sequencing from STS Missions (1998-2001)

Small RNA sequencing data from small extracellular vesicles (sEV) isolated from the plasma of 14 astronauts who flew Space Shuttle missions between 1998 and 2001. The dataset was produced by the National Aeronautics and Space Administration (NASA) and last updated in March 2026. Samples were collected at three time points relative to launch and landing.

Use Cases

• Identify spaceflight-induced alterations in sEV miRNA content based on longitudinal sampling.
• Evaluate the utility of sEV smallRNA as a biomarker for physiological stress based on pre- and post-flight comparisons.
• Analyze temporal changes in molecular cargo based on samples collected at L-10, R-0, and R+3 time points.

Strengths

• Data from 14 astronauts provides a defined cohort size.
• Longitudinal design with three specific sampling time points (L-10, R-0, R+3).
• Focus on small extracellular vesicles (sEV), a specific and biologically relevant carrier.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect temporal bias inherent to the specific STS mission period (1998-2001).

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Small RNA sequencing (sRNAseq) of sEV isolated from peripheral blood plasma.

Time Range

Samples collected from missions flown between 1998 and 2001.

Freshness

Last updated 2026-03-13 19:51:28.974897; freshness should be verified

Geography

Data collected from astronauts; specific geography not stated.