Mechanochemical Synthesis Data for 2,3-Dihydrothiazoles and Thiazolidines

5.3 MB of data from a solvent-free mechanochemical synthesis study. The dataset, authored by Vipin Kumar and last updated on June 4, 2026, describes a cascade reaction for producing 2,3-dihydrothiazoles and thiazolidines from β-ketothioamides and α-bromoketones/1,3-dichloroprop-2-one. The process achieved higher yields within 15 minutes at room temperature compared to traditional solution-based methods.

Use Cases

• Training models for reaction outcome prediction based on substrate scope and functional group compatibility.
• Benchmarking computational methods for stereochemistry assignment based on the described Z-configuration.
• Analyzing the efficiency of solvent-free synthesis methods based on reported yields and reaction times.

Strengths

• Data describes a process with excellent yields and broad substrate scope.
• The method features a short reaction time of 15 minutes and operational simplicity.
• Dataset is 5.3 MB in size, facilitating quick download and inspection.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale ML tasks.

Provenance

Source

Vipin Kumar via figshare

Collection Method

Experimental results from mechanochemical synthesis in a mortar and pestle.

Freshness

Last updated 2026-06-04 20:46:12