Spaceflight Analogue Effects on Salmonella Colonization in a 3-D Intestinal Model

NASA research investigating how Low Shear Modeled Microgravity (LSMMG) culture affects Salmonella Typhimurium colonization in a 3-D biomimetic human colonic epithelium model. The study includes RNA-seq profiling of wild type and delta hfq mutant bacteria and host cell transcriptional responses to infection. The dataset was last updated on March 13, 2026.

Use Cases

• Modeling bacterial gene expression changes under microgravity-like conditions based on RNA-seq data mentioned in the description
• Studying host immune and tissue remodeling responses to Salmonella infection based on host cell transcript analysis
• Investigating the role of the Hfq protein in bacterial adaptation to physical forces based on comparisons between wild type and mutant strains

Strengths

• Data originates from NASA, a leading authority in spaceflight research
• Focuses on a novel 3-D biomimetic intestinal co-culture model, an advanced experimental system
• Includes comparative analysis of wild type and genetically modified (delta hfq) bacterial strains

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experimental study using a spaceflight analogue low fluid shear culture system and RNA-seq profiling

Time Range

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Freshness

Last updated 2026-03-13 19:50:59.523514; freshness should be verified

Geography

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