NASA STS-62 Spaceflight Effects on Bone Loss and Marrow Adiposity in Ovariectomized Rats

NASA research data from a 14-day spaceflight (STS-62) on bone mass and marrow adipose tissue in ovariectomized rats. The dataset contains results from a bone histomorphometry assay, quantifying changes in cancellous bone area, adipocyte number and size, and bone resorption and formation rates. The data was last updated on March 13, 2026.

Use Cases

• Modeling the relationship between bone marrow adiposity and bone loss based on quantified adipocyte number and size changes.
• Analyzing the effects of microgravity on bone resorption and formation coupling based on osteoclast and osteoblast activity metrics.
• Investigating the impact of ovarian hormone deficiency combined with spaceflight on bone density based on cancellous bone area measurements.

Strengths

• Specific quantitative results are provided, such as a 32% lower cancellous bone area and a 306% higher marrow adipose tissue in flight groups.
• The experimental design is clearly described, involving a 14-day spaceflight with ground controls and ovariectomized Fischer 344 rats.
• Data originates from the National Aeronautics and Space Administration (NASA), an authoritative source for spaceflight research.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is stored in a BIN file format, which may require specific tools for access and interpretation.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Bone histomorphometry assay on lumbar vertebrae from ovariectomized rats following a 14-day spaceflight mission (STS-62).

Time Range

Study involved a 14-day spaceflight; specific collection dates are not provided.

Freshness

Last updated 2026-03-13 19:55:24.433804; freshness should be verified.

Geography

Not specified, but research likely conducted as part of a NASA mission.