Spiro-Linked Polyketides from Westerdykella dispersa as iNOS Inhibitors

Taiwanese edible oysters yielded the fungal strain Westerdykella dispersa Ca4–13, from which seven chemical entities were isolated. The dataset includes spectroscopic analysis and anti-inflammatory activity data for these compounds, particularly their inhibition of nitric oxide production in LPS-induced BV-2 microglial cells. The data was authored by Shu-Jung Huang and last updated on 2026-05-28.

Use Cases

• Identify potential anti-inflammatory lead compounds based on IC50 values for nitric oxide inhibition.
• Analyze structure-activity relationships based on the unique 6/6-spiro-linked δ-lactone moiety described for compounds 2 and 3.
• Perform molecular docking studies based on the provided murine iNOS (PDB ID: 1QW4) target and described interaction networks.
• Screen for novel C14 and C28 polyketide scaffolds based on the elucidated structures of westeroic acids A, B, and C.

Strengths

• Includes specific IC50 values ranging from 9.9 to 11.3 μM for anti-inflammatory activity.
• Describes seven characterized chemical entities, including a novel C14 polyketide and two rare C28 polyketides.
• Provides molecular docking analysis using a specific protein target (murine iNOS, PDB ID: 1QW4).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the single source of fungal isolation.

Provenance

Source

figshare, author Shu-Jung Huang.

Collection Method

Chemical investigation and spectroscopic analysis of fermented products from an isolated fungal strain.

Freshness

Last updated 2026-05-28 20:04:18; freshness should be verified.

Geography

Fungal strain isolated from edible oysters (Crassostrea angulata) collected from Taiwan.