Spiro-Linked Polyketides from Westerdykella dispersa as iNOS Inhibitors

Seven chemical entities were isolated from the fermented products of the fungal strain Westerdykella dispersa Ca4–13, collected from edible oysters in Taiwan. Four compounds exhibited anti-inflammatory activity in LPS-induced BV-2 microglial cells, with IC50 values ranging from 9.9 to 11.3 μM. The dataset, authored by Shu-Jung Huang and last updated in May 2026, includes molecular docking analysis results against murine iNOS (PDB ID: 1QW4).

Use Cases

• Identify potential lead compounds for neuroinflammation drug development based on anti-inflammatory activity data.
• Study structure-activity relationships of spiro-linked polyketides based on the described chemical structures.
• Validate molecular docking models for iNOS inhibition based on the provided docking analysis against PDB ID: 1QW4.
• Screen for novel fungal metabolites with specific bioactivity based on the described isolation from Westerdykella dispersa.

Strengths

• Includes specific IC50 values (9.9 to 11.3 μM) for anti-inflammatory activity.
• Describes seven characterized chemical entities, including novel and rare structures.
• Provides molecular docking analysis using a specific protein structure (PDB ID: 1QW4).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the single collection source in Taiwan.

Provenance

Source

figshare

Collection Method

Chemical investigation and spectroscopic analysis of fermented fungal products.

Freshness

Last updated 2026-05-28 20:04:16; freshness should be verified.

Geography

Taiwan (fungal strain isolated from edible oysters Crassostrea angulata)