Stigmatellamines A–D: Cytotoxic Alkaloids from Stigmatella aurantiaca

Four N-alkylpyridinium alkaloids, stigmatellamines A–D, were isolated from the bacterium Stigmatella aurantiaca. Their structures were elucidated through spectroscopic and synthetic approaches, and stigmatellamines A–C exhibited potent cytotoxicity against human B-cell lymphocytes. The dataset was authored by Teruhisa Manome and last updated on April 15, 2026.

Use Cases

• Identify novel cytotoxic compounds based on the described N-alkylpyridinium alkaloid structures.
• Study bacterial metabolite induction based on the described mechanism involving membrane vesicles from Burkholderia plantarii.
• Validate spectroscopic analysis methods based on the structural elucidation approach described for the alkaloids.
• Screen for potential anti-cancer agents based on the reported cytotoxicity against RPMI8226 human B-cell lymphocytes.

Strengths

• Contains data on four newly isolated alkaloid compounds with elucidated structures.
• Includes bioactivity results showing potent cytotoxicity for three of the compounds against a specific human cell line.
• Dataset size is 112.4 MB, suggesting it may contain detailed supplementary files.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Compounds were isolated from Stigmatella aurantiaca and their structures elucidated through spectroscopic and synthetic approaches.

Freshness

Last updated 2026-04-15 19:14:25; freshness should be verified.