Structural Diversity and Analytical Characterization of Acylhomocarnitines

Jaclyn Weinberg's dataset describes liquid chromatography–mass spectrometry methods for measuring fatty acyl-homocarnitines, a previously uncharacterized family of mammalian metabolites. It includes sample preparation and chromatographic methods to separate and analyze isomers in mouse tissue extracts. The dataset was last updated on 2026-05-13.

Use Cases

• Developing LC-MS methods for metabolite separation based on the described sample preparation and chromatographic techniques.
• Identifying and characterizing acyl-homocarnitine metabolites based on the described ion dissociation patterns.
• Differentiating acyl-homocarnitines from isomeric acyl-carnitines based on the established diagnostic product ions.
• Conducting in vitro isotope tracer studies for metabolite production based on the described 13C3-homocarnitine methods.

Strengths

• Dataset provides specific analytical methods for a previously uncharacterized metabolite family.
• Includes ion dissociation analyses to establish diagnostic product ions for isomer distinction.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 14.2 KB, indicating limited scope.

Provenance

Source

Jaclyn Weinberg via figshare

Collection Method

Liquid chromatography–mass spectrometry analysis of mouse tissue extracts.

Freshness

Last updated 2026-05-13 20:05:43; freshness should be verified.