BPR1M492: Structural Data for a Potent Opioid Analgesic Compound

Po-Wei Chang published structural data for a series of N-(1,2,3,4-tetrahydro-3-isoquinolinylmethyl)benzamide compounds on figshare in 2026. The dataset includes information on BPR1M492 (compound 56), a potent μ-opioid receptor agonist. The compound demonstrated potent in vivo antinociception at 0.027 mg/kg and rapid pain relief within 5 minutes of subcutaneous injection.

Use Cases

• Structure-activity relationship (SAR) analysis based on the described benzamide compound series
• Modeling opioid receptor binding based on the compound's profile as a MOR agonist
• Comparing withdrawal symptom profiles based on the described milder effects versus TRV130
• Assessing physicochemical properties based on the description of the compound as a stable crystalline solid

Strengths

• Specific in vivo potency data is provided (0.027 mg/kg for antinociception)
• Key pharmacological profiles are described (MOR agonist, cAMP/β-arrestin-2 signaling bias)
• Comparative withdrawal symptom data is mentioned versus TRV130

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small (192.9 KB), indicating limited scope

Provenance

Source

figshare

Freshness

Last updated 2026-06-01 19:38:44; freshness should be verified