Tranilast Derivatives: Anti-Poxvirus Activity and Mechanism Data

A 2026 dataset from figshare contains activity data for 24 synthesized tranilast derivatives against orthopoxviruses. The data includes EC50 values for the most potent compound (8l) against VTT and monkeypox clade IIb, and its viral inhibition rate in a nude mouse model. The dataset was created by Yanan Ni and shared under a CC-BY-NC-4.0 license.

Use Cases

• Evaluating structure-activity relationships based on the 24 synthesized tranilast derivatives
• Screening for antiviral lead compounds based on EC50 values from the VTT-Fluc assay
• Studying dual-target inhibition mechanisms based on the described action on viral A17L and mRNA methyltransferase
• Assessing in vivo efficacy based on the viral inhibition rate reported in the nude mouse model

Strengths

• Includes specific potency metrics: EC50 values of 6.1 μM and 47.1 μM for compound 8l
• Reports in vivo validation: an 88.2% viral inhibition rate at 90 mg/kg oral dose
• Describes a clear mechanistic hypothesis: covalent adduct formation via Michael addition

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory synthesis and biological assays described in the associated research.

Freshness

Last updated 2026-05-01 02:45:48