Tranilast Derivatives: Anti-Poxvirus Activity and Mechanism Data

A 2026 study by Yanan Ni presents data on 24 synthesized tranilast derivatives evaluated for anti-orthopoxvirus activity. Compound 8l showed EC50 values of 6.1 μM against VTT-Fluc and 47.1 μM against monkeypox clade IIb, with an 88.2% viral inhibition rate in a nude mouse model. The dataset includes results from mechanistic studies identifying A17L and mRNA methyltransferase as dual targets.

Use Cases

• Screen for covalent lead compounds based on α, β-unsaturated acrylamide warheads.
• Evaluate antiviral activity against orthopoxviruses using EC50 values.
• Investigate dual-target inhibition mechanisms involving viral A17L and mRNA methyltransferase.
• Analyze structure-activity relationships of tranilast derivatives.

Strengths

• Includes specific potency metrics: EC50 values of 6.1 μM and 47.1 μM for two viruses.
• Reports in vivo efficacy: 88.2% viral inhibition rate in a nude mouse model at 90 mg/kg.
• Mechanistic detail is provided, identifying two specific protein targets and the covalent binding mode.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 561.4 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory synthesis and biological assays described in the associated research.

Freshness

Last updated 2026-05-01 02:45:49; freshness should be verified.