Proteasome Assembly Structural Transitions from Cryo-EM Data

Structural biology data from Petra Wendler details the stepwise assembly of proteasome core particles. It includes PDB and EMDB files with validation reports, totaling 2.8 GB of data. The dataset was last updated in March 2026 and is licensed under CC BY 4.0.

Use Cases

• Analyze PDB and EMDB structures to model the conformational changes during proteasome maturation stages like 13 S and 15 S.
• Use validation reports to assess the quality and reliability of structural models for the proteasome assembly process.
• Investigate the structural roles of specific factors, such as the chaperone Ump1, in proteasome biogenesis and autoactivation.

Strengths

• Dataset size of 2.8 GB indicates a substantial collection of structural biology data files.
• Includes multiple data types (PDB, EMDB, validation reports) for cross-referencing structural models.
• Focuses on a specific biological process with relevant tags like Cryo-EM, Proteasome Biogenesis, and specific assembly intermediates (13 S, 15 S).

Limitations

• Sample data and column descriptions are unavailable, making initial data exploration and programmatic parsing difficult.
• The dataset consists of specialized binary formats (PDF, MRC, PDB) requiring specific software tools for analysis.
• Lacks metadata on the number of individual structures or experiments, making the dataset's granular scale unclear.

Provenance

Source

figshare, authored by Petra Wendler.

Collection Method

Presumably derived from Cryo-EM experiments and subsequent structural modeling.

Freshness

Last updated on 2026-03-25.