Structure-Activity Relationship Studies for 1,3,4-Thiadiazole-Based Bacterial Carbonic Anh

A dataset from figshare, uploaded by Prabhakara R. Tharra and last updated on 2026-05 06, containing structure-activity relationship studies for acetazolamide-based analogs. The data likely includes in vitro and in vivo evaluation results for compounds tested as bacterial carbonic anhydrase inhibitors against drug-resistant Neisseria gonorrhoeae.

Use Cases

• Modeling quantitative structure-activity relationships (QSAR) based on compound activity data mentioned in the description
• Prioritizing lead compounds for in vivo pharmacokinetic analysis based on in vitro ADME evaluation results
• Identifying structural features correlated with efficacy against drug-resistant Neisseria gonorrhoeae based on the described SAR studies

Strengths

• Includes in vivo efficacy data from an infected mouse model, as described
• Contains data on orally bioavailable and metabolically stable compounds with low cytotoxicity
• File size is 314.0 KB, indicating a focused and manageable dataset

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

figshare

Collection Method

Likely contains experimental results from structure-activity relationship studies and in vivo testing.

Time Range

null

Freshness

Last updated 2026-05-06 09:34:15; freshness should be verified

Geography

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