Triazole-Linked Sesamol Conjugates: Antifungal Efficacy Against Candida albicans

Karanvir Singh designed and synthesized a series of triazole-linked sesamol conjugates as potential antifungal agents. The dataset includes in vitro and in vivo efficacy data, such as MIC and MFC values, for these compounds against pathogenic Candida strains. It was last updated on April 28, 2026, and is shared via figshare under a CC-BY-NC-4.0 license.

Use Cases

• Structure-activity relationship analysis based on the series of designed conjugates
• Lead compound identification based on reported MIC and MFC values
• In vivo model validation based on the Galleria mellonella infection rescue data
• Drug resistance assessment based on the 30-day resistance induction assay results

Strengths

• Includes specific potency metrics for a lead compound (MIC = 1.9 μM, MFC = 3.9 μM)
• Reports results from multiple experimental assays (biofilm eradication, resistance induction, in vivo model)
• Data is associated with a specific, peer-reviewed research approach (e-pharmacophore and molecular hybridization)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small (10.7 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory synthesis and biological evaluation of chemical compounds.

Freshness

Last updated 2026-04-28 06:33:45; freshness should be verified