Nostolysamides: Structure, Biosynthesis, and Bioactivity Data

Nostolysamides are a class of acylated lanthipeptides with demonstrated antibacterial and antifungal activity. The dataset likely contains results from genome mining, heterologous expression in Escherichia coli, and in vitro studies of the acetyltransferase NpuN. Enleyona Weir published this research on figshare in April 2026.

Use Cases

• Study the structure-activity relationship of lanthipeptides based on described ring patterns and acyl group conjugation.
• Investigate the substrate specificity of the acetyltransferase NpuN based on its described activity with various acyl-CoA substrates.
• Model the biosynthesis pathway of class II lanthipeptides based on the described co-expression of NpuA and NpuM.
• Screen for novel antimicrobial compounds based on the described activity against Candida species and bacteria via membrane disruption.

Strengths

• Includes data on a novel class of lanthipeptides (nostolysamides) with confirmed bioactivity.
• Describes a specific biosynthetic gene cluster and enzyme (NpuN) with broad substrate specificity.
• Results are based on multiple experimental methods, including tandem mass spectrometry and mutagenesis studies.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific bacterial strains and methods used.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from genome mining, heterologous peptide production, and in vitro enzymatic assays.

Freshness

Last updated 2026-04-25 04:04:42; freshness should be verified.