STS-135 Cerebellum Transcriptomics: Mouse Gene Expression After Spaceflight

Mice were flown onboard the STS-135 space shuttle mission and returned to Earth for analysis. Cerebellum tissue samples were collected within 3-4 hours of landing and snap-frozen for RNA sequencing at the UCI Genomics High Throughput Facility. The dataset was published by the National Aeronautics and Space Administration and last updated in March 2026.

Use Cases

• Identify gene expression changes in the cerebellum induced by spaceflight based on the transcriptomic data.
• Study the molecular response of neural tissue to microgravity and re-entry stress based on the post-landing sample collection protocol.
• Compare spaceflight-induced transcriptomic signatures to terrestrial models of neural stress or adaptation.

Strengths

• Samples were collected under a controlled protocol, with tissue harvested within 3-4 hours of landing from the STS-135 mission.
• Data originates from the National Aeronautics and Space Administration, a primary source for spaceflight experiments.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Cerebellum tissue collected from mice flown on the STS-135 space shuttle, snap-frozen, and analyzed via RNA sequencing at the UCI Genomics High Throughput Facility.

Freshness

Last updated 2026-03-13 19:34:06.604006; freshness should be verified.